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Novak Djokovic's US Open ended with a first-round defeat to Mariano Navone, marking his earliest Grand Slam exit in 20 years with a score of 7-6 (7/5), 5-7, 4-6, 6-2, 6-1, and ending a streak of 78 consecutive first-round wins since 2006. Djokovic, who is currently 39 and struggling with a long-term health issue that causes severe physical discomfort, expressed frustration over his ongoing condition, which he noted has affected him for many years, particularly in hot and humid conditions. Despite reaching the semifinals of Wimbledon and the final of the Australian Open earlier in the year, he acknowledged that he is currently unable to perform at a high level and is unsure if his health issue can be resolved.

Novak Djokovic, at 39, suffered a shocking first-round defeat at the US Open to Mariano Navone, losing 7-6 (5), 5-7, 4-6, 6-2, 6-1 in a marathon match that lasted four hours and 36 minutes, marking his earliest exit in a Grand Slam since 2006. Djokovic, who recorded 70 unforced errors and experienced physical ailments including cramping and vomiting, admitted to struggling with his overall health throughout the match. This loss raises questions about Djokovic's future in tennis, as it coincided with the 21st anniversary of his US Open debut.